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Metadoxine

Uses of Metadoxine

Metadoxine is a medicine used in some countries as supportive treatment for acute alcohol intoxication and alcohol-related liver injury.

It is commonly used for:

  • Acute alcohol intoxication: May support alcohol metabolism as part of monitored medical care.
  • Alcohol-related liver disease: May be used as an add-on to standard care to support liver-cell function.

It does not replace emergency assessment, alcohol-withdrawal treatment or support for alcohol dependence.

Side effects of Metadoxine

  • Nausea and vomiting

  • Headache and dizziness

  • Fatigue

  • Skin rash and itching

How Metadoxine works

  • Metadoxine is a salt formed from pyridoxine and pidolic acid.
  • Its exact clinical mechanism is not fully understood. It may influence enzymes involved in alcohol metabolism and help restore antioxidant defences such as glutathione in liver cells.
  • These effects may support recovery in alcohol-related conditions, but the medicine should not be described as guaranteeing rapid alcohol removal or preventing liver injury.

Certified content

Written By

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Dr. Michelle FrankMedical Content Writer| 10 years

Doctor of Medicine

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi RoshaMedical Content Writer| 10 years

BAMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Metadoxine is available in the form of tablets for oral administration.

  • This medicine is also administered as an intramuscular or intravenous injection, especially in cases of acute alcohol intoxication.

Age and Dose Restrictions

  • Metadoxine is meant for use in adults, and children over the age of 12.

Contraindications

  • Metadoxine is contraindicated in patients who have known allergies to pyridoxine or pidolic acid.

  • This medicine should not be used in patients with severe liver impairment, due to its potential impact on liver function.

Other Medications to Avoid

  • Metadoxine may interact with sedative agents (such as benzodiazepines) and opioids (such as morphine, methadone and oxycodone).

Overdose and Missed Dose

  • An overdose of Metadoxine may cause symptoms such as nausea, vomiting, and abdominal discomfort. If an overdose is suspected, seek immediate medical attention or visit the nearest hospital. Do not attempt to manage these symptoms at home without medical guidance.
  • If you miss a dose of Metadoxine, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • For mild nausea or vomiting, try taking your medicine with a light snack or meal.

  • If you experience drowsiness or dizziness after taking Metadoxine, ensure that you are well-rested before undertaking activities that require concentration.

Use in Driving and Operating Machinery

  • Metadoxine may cause dizziness or drowsiness. If you experience these side effects, it is advised to avoid driving or operating heavy machinery.

Use in Pregnancy and Lactation

  • The use of Metadoxine during pregnancy and lactation should only be considered if the potential benefits outweigh the risks. It is crucial to consult your doctor before using this medicine if you are pregnant or breastfeeding.

Caution in Other Conditions

  • Patients with kidney disease should exercise caution while taking Metadoxine, as dose adjustments may be required.

Special Dietary and Lifestyle Recommendations

  • Regular check-ups can aid in monitoring liver health, especially for those taking Metadoxine for an extended duration.

Frequently asked questions

No, Metadoxine is not a steroid. It is primarily a medicine used to manage alcohol intoxication and alcohol dependence.

Metadoxine is not associated with any direct effects on sleep. It is primarily used to treat alcohol intoxication and liver conditions, with no known impact on sleep patterns.

Metadoxine is not associated with effects on fertility. It is mainly used for managing alcohol-related conditions and liver health, with no known impact on reproductive health.

Metadoxine appears to be well tolerated with few serious adverse effects. However, the safety of long-term use beyond a few months is not well studied. You should only use Metadoxine as directed by your doctor.

Metadoxine starts reducing blood alcohol levels and improving symptoms within a few hours of first dose administration.

There are no specific guidelines on the best time to take Metadoxine. For specific guidelines on the best time to take Metadoxine, consult your doctor.

Yes, Metadoxine may cause allergic reactions such as skin rashes, itching or shortness of breath. If you experience these symptoms, stop taking the medication immediately and consult your doctor.

Metadoxine is used to treat alcohol intoxication, alcoholic fatty liver, and non-alcoholic fatty liver disease. It helps the body remove alcohol faster, protects liver cells from damage, and supports liver recovery and healthy liver function.

Terms & Conditions


List of medicines for Metadoxine

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Alcoliv Tablet 10
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Metadoxil 60 Mg Injection 5 Ml
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Alcofast 500 Mg Tablet 10
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