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Mesalazine

Drugs For Inflammatory Bowel Disease

Uses of Mesalazine

Mesalazine is an aminosalicylate medicine used to treat and prevent flare-ups of ulcerative colitis, a chronic inflammatory bowel condition.

Mesalazine is commonly used for:

  • Mild-to-moderate ulcerative colitis: Reduces inflammation in the colon and rectum, easing symptoms such as abdominal pain, diarrhoea, and rectal bleeding during active flare-ups.
  • Maintenance treatment for ulcerative colitis: Used long-term to help prevent further flare-ups and maintain remission once symptoms have improved.
  • Proctitis (inflammation of the rectum): Used in suppository or enema form to treat inflammation localised to the rectum.
  • Left-sided colitis: Used in enema form to treat inflammation affecting the left side of the colon.

Side effects of Mesalazine

  • Nausea
  • Abdominal pain
  • Diarrhea
  • Headache

How Mesalazine works

  • Mesalazine works by acting directly within the lining of the colon to reduce inflammation, rather than acting throughout the whole body.
  • It belongs to the aminosalicylate class of medicines. Once it reaches the colon, Mesalazine works locally on the inflamed bowel lining by inhibiting the production of pro-inflammatory chemicals called prostaglandins and leukotrienes. These chemicals are normally released during inflammation and contribute to the tissue damage, pain, and irritation seen in ulcerative colitis.
  • By blocking their production, Mesalazine reduces inflammation, swelling, and irritation in the colon lining, which helps relieve symptoms during a flare-up and supports healing of the bowel tissue.
  • Different formulations of Mesalazine (tablets, granules, suppositories, and enemas) are designed to release the medicine at specific points along the digestive tract, ensuring it reaches and acts directly on the affected area of the colon or rectum.

Certified content

Written By

docImg
Dr. Sachin SinghMedical Team Lead & Reviewer| 7 years

MBBS

Reviewed By

Dr. Mandeep Chadha
Dr. Mandeep ChadhaLead Medical Content Reviewer| 12 years

MBBS, DNB (OBGY)

Expert Advice

Dosage Forms Available

  • Mesalazine is available for use via the oral route (tablet, capsule) and anal route (suppository).

Age and Dose Restrictions

  • This medicine is meant for adults.

Contraindications

  • The medication is not recommended in patients with a known allergy to Mesalazine and severe liver and kidney conditions.

Other Medications to Avoid

  • Inform your doctor if you are taking non-steroidal anti-inflammatory drugs such as aspirin or ibuprofen, immunosuppressants like azathioprine, or any other medications.

Overdose and Missed Dose

  • An overdose of Mesalazine may cause symptoms such as nausea, vomiting, diarrhoea, tinnitus (ringing in the ears), and breathing difficulties. If you observe these symptoms, inform your doctor and follow their advice promptly.
  • If you forget to take a dose of Mesalazine, take it as soon as you remember. If it is nearly time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to compensate for the missed one.

Management of Side Effects

  • Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

Use in Driving and Operating Machinery

  • This medication will not impair your ability to drive and operate heavy machinery.

Use in Pregnancy and Lactation

  • Consult your doctor before taking or using this medicine in pregnancy or breastfeeding.

Caution in Other Conditions

  • Patients with a history of peptic ulcers should be cautious.

Special Dietary and Lifestyle Recommendations

  • Maintain a low-fat diet and include vitamin C-rich foods like bell peppers, spinach, parsley, and berries to support faster healing.
  • Consume foods and drinks high in Omega-3 fatty acids, such as flaxseeds, walnuts, soybean oil, salmon, and tuna, to help reduce pain, swelling, and inflammation.
  • Increase your intake of fibre-rich foods like fruits and vegetables, and opt for smaller, frequent meals throughout the day.
  • Stay hydrated by drinking small amounts of water regularly. If you are lactose intolerant, consider reducing your milk intake.
  • Avoid foods high in sugar, fat, and processed ingredients, as they may trigger inflammation. Limit alcohol consumption, as it can harm the stomach and intestines and interfere with the absorption of essential nutrients.

Frequently asked questions

Mesalazine may start showing effects within a few days, but noticeable improvement in symptoms usually occurs within two to four weeks. The response time can vary depending on the severity of the condition.

Inform your doctor if you have kidney or liver disease, asthma, or a history of allergic reactions to salicylates (e.g., aspirin). Stay hydrated to prevent kidney issues and follow your prescribed dosage to avoid complications.

No, do not stop taking Mesalazine without consulting your doctor. Stopping it suddenly may lead to symptom flare-ups or worsening of the condition.

Patients with kidney or liver problems should use Mesalazine with caution. Regular kidney and liver function tests may be required to monitor any potential adverse effects.

Mesalazine is not known to significantly impact fertility in men or women. However, if you are planning a pregnancy, consult your doctor for guidance.

Terms & Conditions

List of medicines for Mesalazine

Mesalo Foam 82Gm
Mesalo Foam 82Gm
Cipla Ltd.
Pack of 82 GM
₹1170.96
MRP ₹1463.7
20% OFF
Mesaline 400 Tablet Dr 10
Mesaline 400 Tablet Dr 10
Prevego Healthcare & Research Pvt.ltd.
Pack of 10 Units
₹42.32
MRP ₹84.63
49.99% OFF
Mesalmile 400 Tablet 10
Mesalmile 400 Tablet 10
Steris Healthcare Private Limited
Pack of 10 Units
₹48.12
MRP ₹82.5
41.67% OFF
Mesacol 1g Suppositories 5
Mesacol 1g Suppositories 5
Sun Pharma Laboratories Ltd.
Pack of 5 Units
₹185.25
MRP ₹231.56
20% OFF
Vegaz Od Tablet 10
Vegaz Od Tablet 10
Dr. Reddys Laboratories Ltd
Pack of 10 Units
₹309.38
MRP ₹386.72
20% OFF
Mosart Od Tablet 10
Mosart Od Tablet 10
Cadila Pharmaceuticals Ltd
Pack of 10 Units
₹258.75
MRP ₹323.44
20% OFF
Rowasa 2Gm Sachet 1
Rowasa 2Gm Sachet 1
Abbott India Ltd.
Pack of 1 GM
₹108.7
MRP ₹135.87
20% OFF

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CIN: U62099MH2019PTC320566
Telephone:09240250346

Grievance Officer

Name: Kishor Kumar

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