Imeglimin

Dosage Forms Available

• Imeglimin can be taken orally (tablet).

Age and Dose Restrictions

• Imeglimin is indicated for use in adults aged 18 and above.

Contraindications

• Imeglimin should not be used in patients with severe ketosis, diabetic ketoacidosis, diabetic coma or pre-coma, type 1 diabetes, severe infection, before or after surgery, or severe injury.
• Patients with a known hypersensitivity to imeglimin or any of its components should not use it.
• Imeglimin is not recommended for patients with an eGFR below 10 mL/min/1.73 m², including patients undergoing dialysis.

Other Medications to Avoid

• Imeglimin can potentially interact with antiepileptic medications (such as lamotrigine and topiramate), antidepressants (like bupropion), heart medication (such as digoxin), anti-anginal medication (like ranolazine), antibiotics (such as cephalexin and ciprofloxacin) and anti-ulcer medication (like cimetidine).

Overdose and Missed Dose

• If an overdose of Imeglimin is suspected, seek medical attention immediately. In case of an overdose, supportive treatment should be provided according to the symptoms, including monitoring for and treating hypoglycaemia.

• If you miss a dose of Imeglimin, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• Drinking plenty of water might help manage gastrointestinal side effects like nausea, vomiting, abdominal pain, and diarrhea.

• If you experience headaches after taking Imeglimin, try to rest and relax. A hot or cold compress may also help relieve the discomfort.

Use in Driving and Operating Machinery

• Imeglimin does not typically interfere with the ability to drive or operate machinery. However, if you experience any side effects like dizziness or tiredness, it may be best to avoid these activities until such symptoms subside.

Use in Pregnancy and Lactation

• Pregnant women or women who may become pregnant should use Imeglimin only as advised by their doctor. The doctor may recommend using insulin if needed.
• Women who are breastfeeding should consult their doctor before using Imeglimin. The doctor will provide appropriate advice after considering the benefits of treatment and breastfeeding.

Caution in Other Conditions

• Patients with impaired liver or kidney function should exercise caution when taking Imeglimin. Regular monitoring of renal function is advised before and during treatment with this medicine.

Special Dietary and Lifestyle Recommendations

• Patients should also aim for adequate rest and stress management strategies to improve their overall health and well-being.