Furazolidone is a synthetic antibacterial and antiprotozoal medicine used to treat bacterial and parasitic infections of the gastrointestinal tract.
Furazolidone is commonly used for:
• Infectious diarrhoea: Treats acute infectious diarrhoea caused by susceptible bacteria.
• Bacterial gastroenteritis: Manages gastrointestinal infections caused by Escherichia coli (E. coli), Salmonella, Shigella, and Vibrio cholerae bacteria.
• Giardiasis: Treats intestinal infection caused by the parasite Giardia lamblia, characterised by watery diarrhoea, bloating, and digestive discomfort.
• Dysentery: Used to treat bacterial and amoebic dysentery causing bloody diarrhoea and abdominal cramping.
• Cholera: Effective against Vibrio cholerae, the bacterium responsible for cholera infections.
Nausea
Vomiting
Diarrhoea
Abdominal pain
Headache
Furazolidone works by disrupting the essential biochemical processes that bacteria and certain parasites need to survive and reproduce.
It is converted inside the microbial cell into reactive intermediates (reduced metabolites) by enzymes present in susceptible bacteria and protozoa. These reactive products inhibit several microbial enzyme systems involved in:
This dual disruption of both nucleic acid and protein synthesis makes Furazolidone bactericidal (it kills bacteria) rather than merely bacteriostatic (growth-stopping). It is effective against a broad range of gram-negative enteric bacteria and some protozoa such as Giardia lamblia.

Doctor of Medicine

BAMS, FMC, MD Resident
Furazolidone is available in two dosage formulations: tablets and oral suspension, both of which are taken orally.
The use of Furazolidone is approved for adults and children above 2 years of age.
Furazolidone is contraindicated in patients with known hypersensitivity to Furazolidone or any other nitrofurans.
It should not be used by patients with impaired liver or kidney function without careful medical supervision.
Patients suffering from neurological conditions such as seizures, numbness, or pain in the hands or feet should avoid using this medicine.
Furazolidone may interact with Monoamine oxidase inhibitors (such as selegiline, rasagiline, or phenelzine), other antibiotics (for example, tetracyclines, chloramphenicol), and anticoagulants such as warfarin.
If you miss a dose of Furazolidone, take it as soon as you remember. If it is nearly time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time. Completing the full prescribed course is important to ensure the infection is completely treated.
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drink plenty of water to manage nausea or vomiting.
Resting in a dark and quiet room can help manage headaches or dizziness.
Though Furazolidone does not typically cause drowsiness, it may cause dizziness in some people. Therefore, it is recommended to avoid driving or operating heavy machinery until you know how this medicine affects you.
The safety of Furazolidone during pregnancy and lactation has not been established. It is recommended to consult your doctor before using this medicine during these periods.
Patients with liver or kidney disease should use Furazolidone with caution and under close medical supervision, as these conditions may affect the way the medicine is metabolised in the body.
Patients with a history of seizures or neurological conditions should inform their doctor before taking Furazolidone.
Maintaining good hygiene practices, particularly hand cleanliness, can help prevent the spread of bacterial and protozoal infections that Furazolidone is used to manage.
Eating balanced meals at regular intervals can help support the body's immune system.
Avoiding contaminated water or food can also help prevent gastrointestinal infections caused by bacteria and protozoa.
Frequently asked questions
No, Furazolidone is not a steroid. It is a synthetic antibacterial and antiprotozoal medication, which belongs to the nitrofuran class.
There is no specific evidence or scientific data to suggest that Furazolidone directly affects sleep. However, some patients may experience drowsiness as a side effect of this medicine.
There is no established scientific evidence to indicate that Furazolidone can affect fertility in humans. However, if you have concerns about this, you should discuss them with your doctor.
You should avoid consuming alcohol and foods high in tyramine, such as aged cheeses, cured meats, and soy products, while taking Furazolidone as these can potentially cause a hypertensive crisis.
Yes, Furazolidone can be taken daily, but the duration and frequency should be as per your doctor's recommendation.
The time it takes for Furazolidone to work can vary depending on the type and severity of the infection. It is essential to follow your doctor's instructions for the best results.
The best time to take Furazolidone would be as directed by your doctor. It can be taken with or without food.
Furazolidone in other salts
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