Fosaprepitant

Dosage Forms Available

• Fosaprepitant can be administered intravenously (powder which is reconstituted for injection).

Age and Dose Restrictions

• This medicine is intended for use by adults and children aged 6 months and older.

Contraindications

• Fosaprepitant is contraindicated in patients with a known hypersensitivity to any component of the product or aprepitant. It should not be used by patients who are currently taking pimozide due to potential increases in plasma concentrations of pimozide, which could lead to serious or life-threatening reactions.

Other Medications to Avoid

• Fosaprepitant may interact with certain sedatives (such as midazolam) and steroids (such as dexamethasone and methylprednisolone), as well as cancer medicines (e.g., etoposide, vinorelbine).

Overdose and Missed Dose

• Fosaprepitant is administered by a healthcare professional as an intravenous infusion, which minimises the risk of accidental overdose. If too much is given, side effects such as nausea, headache, or dizziness may be more pronounced. Seek medical attention immediately if an overdose is suspected.

• As Fosaprepitant is given by a healthcare professional as part of a chemotherapy schedule, any missed doses are managed by your doctor. If you have concerns about your antiemetic treatment plan, speak with your oncologist or nurse directly.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• For side effects like fatigue and asthenia, try resting and limiting your activities.

• If you experience diarrhoea, drink plenty of fluids to stay hydrated.

• In case of nausea or vomiting, try eating smaller, more frequent meals instead of three large meals a day.

Use in Driving and Operating Machinery

• Fosaprepitant may cause drowsiness or dizziness in some individuals. Therefore, it is advised to avoid driving or operating heavy machinery until you know how this medicine affects you.

Use in Pregnancy and Lactation

• The use of Fosaprepitant in pregnant women should only be considered if the potential benefit outweighs the potential risk to the fetus. Therefore, a decision should be made whether to discontinue breastfeeding or to discontinue using this medicine, taking into account the importance of the medicine to the mother.

Caution in Other Conditions

• Fosaprepitant may affect the International Normalised Ratio (INR) in patients on chronic warfarin therapy. Regular monitoring is advised for these patients.

• Patients with severe hypersensitivity reactions should exercise caution when using this medicine.

Special Dietary and Lifestyle Recommendations

• Hydration is crucial as chemotherapy and associated medications can cause dehydration.

• Stress management techniques like meditation, yoga or mindfulness can help manage emotional stress associated with chemotherapy.