Bupropion

Dosage Forms Available

• Bupropion can be taken orally (immediate-release (IR) tablets, sustained-release (SR) tablets and extended-release (XL) tablets).

Age and Dose Restrictions

• Bupropion is primarily intended for adults.

Contraindications

• Bupropion is contraindicated in patients with a history of seizures or eating disorders such as anorexia or bulimia because of the increased risk of seizures associated with its use. It is also contraindicated in individuals who are currently abstaining from alcohol, benzodiazepines, barbiturates, or antiepileptic medicines due to the risk of withdrawal seizures. Lastly, individuals with known hypersensitivity or allergy to Bupropion should avoid its use.

Other Medications to Avoid

• Bupropion may interact with monoamine oxidase inhibitors (MAOIs such as selegiline or phenelzine), antipsychotics (like quetiapine or risperidone), bronchodilators (like theophylline, doxofylline), and systemic corticosteroids (such as prednisolone or dexamethasone).

Overdose and Missed Dose

• In case of an overdose of Bupropion, immediate medical attention should be sought. Overdose symptoms can include hallucinations, loss of consciousness, heart palpitations, and seizures.

• If you miss a dose of Bupropion, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your usual dosing schedule. Do not double your dose to make up for the missed one.

Management of Side Effects

Most side effects of Bupropion are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience severe side effects or worsening symptoms, please consult your doctor.

• Drinking plenty of water can help manage side effects such as dry mouth and constipation.

• If you experience insomnia, try taking your last dose of the day earlier to avoid interference with sleep.

Use in Driving and Operating Machinery

• Bupropion may cause dizziness, confusion or impaired judgement. Therefore, caution should be exercised when driving or operating heavy machinery while taking Bupropion.

Use in Pregnancy and Lactation

• It is advised to consult a doctor before using Bupropion during pregnancy or breastfeeding. The benefits of Bupropion must be weighed against potential risks to the foetus or baby.

Caution in Other Conditions

• Patients with liver or kidney impairment may need adjusted doses of Bupropion. Similarly, elderly patients and those with a history of head trauma or seizures should exercise caution when taking Bupropion due to an increased risk of seizures.

Special Dietary and Lifestyle Recommendations

• Practice relaxation techniques like yoga, meditation, or deep breathing exercises to help manage stress and anxiety, which can exacerbate depression or increase nicotine cravings.