Home/Drugs By Ailments / Benzathine Penicillin G

Benzathine Penicillin G

Uses of Benzathine Penicillin G

Benzathine Penicillin G is a long-acting penicillin antibiotic used to treat and prevent certain bacterial infections.

Benzathine Penicillin G is commonly used for:

• Syphilis: Treats infection caused by the bacterium Treponema pallidum at various stages.
• Yaws, bejel, and pinta: Manages these bacterial skin and bone infections common in certain tropical regions.
• Rheumatic fever prevention: Given regularly to prevent recurrent rheumatic fever and reduce the risk of rheumatic heart disease.
• Streptococcal throat infections: Treats mild to moderate upper respiratory tract infections caused by susceptible streptococcal bacteria.
• Prevention of bacterial endocarditis: Used before certain dental procedures in patients at high risk of this heart infection.

Side effects of Benzathine Penicillin G

  • Injection site pain, swelling, or redness

  • Low-grade fever

  • Nausea and vomiting

  • Headache

  • Fatigue

How Benzathine Penicillin G works

Benzathine Penicillin G is a penicillin-class antibiotic.

It works by binding to and blocking penicillin-binding proteins, which are enzymes bacteria need to build and maintain their cell walls. Without a properly formed cell wall, the bacterial cell becomes unstable and breaks apart.

Because it is formulated to release slowly into the bloodstream after an intramuscular injection, Benzathine Penicillin G provides a long duration of antibacterial action, which is why it is often used for infections that need sustained treatment or regular prophylactic dosing.

Certified content

Written By

docImg
Dr. Michelle FrankMedical Content Writer| 10 years

Doctor of Medicine

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi RoshaMedical Content Writer| 10 years

BAMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Benzathine Penicillin G is available for use via the intramuscular route in the form of a suspension for injection.

Age and Dose Restrictions

  • This medicine is meant for both adults and children of age above 12 years.

Contraindications

  • Benzathine Penicillin G is contraindicated in patients with a history of severe allergic reactions to any penicillin antibiotic.

  • It is also contraindicated in patients with a history of anaphylaxis to any allergen.

Other Medications to Avoid

  • This medicine can interact with antigout agents (such as probenecid), antimetabolites (such as methotrexate), and aminoglycosides (like gentamicin and neomycin).

Overdose and Missed Dose

  • This medicine is given as an intramuscular injection by a healthcare professional, so overdose is uncommon. If you notice symptoms such as a severe allergic reaction, difficulty breathing, or swelling after an injection, seek medical help immediately.
  • If this medicine is being given on a regular schedule to prevent recurrent infection, contact your doctor as soon as possible if you miss a scheduled injection, so it can be rearranged. Do not attempt to self-administer a missed or extra dose.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • Drinking plenty of fluids can help manage side effects such as nausea and diarrhoea.

  • Rest techniques can help manage the feelings of fatigue.

  • Cool compresses or a gentle massage can help manage the pain, swelling or redness at the injection site.

Use in Driving and Operating Machinery

  • This medication may affect your ability to drive or operate heavy machinery due to side effects such as dizziness. Avoid such activities if these symptoms occur.

Use in Pregnancy and Lactation

  • It is advisable to consult your doctor before using this medicine during pregnancy and breastfeeding.

Caution in Other Conditions

  • Benzathine Penicillin G should be used with caution in patients with a history of allergies, especially to penicillins or cephalosporins.

  • Patients with kidney dysfunction may require a reduced dosage of this medicine.

Special Dietary and Lifestyle Recommendations

  • Maintain good personal hygiene to prevent recurrent infections.

  • Regular check-ups with your doctor can help monitor the progress and effectiveness of the medication.

  • If you have been diagnosed with a sexually transmitted disease, ensure you follow safe sex practices to avoid spreading it to others.

Frequently asked questions

Benzathine Penicillin G is not associated with influencing drowsiness. However, individual reactions can vary, and if you experience any unusual symptoms, you should consult your doctor.

Benzathine Penicillin G is not directly associated with affecting weight gain. If you notice any significant weight changes, it is advisable to consult your doctor.

Benzathine Penicillin G is not associated with affecting menstrual periods. If you notice any changes in your menstrual pattern while on this medication, please consult your doctor.

Yes, Benzathine Penicillin G usually requires a prescription from a doctor and is not available over the counter.

No, Benzathine Penicillin G is not a steroid. It is an antibiotic medicine used to manage certain bacterial infections.

Benzathine Penicillin G stays in the body for an extended period after being injected into a muscle. A single intramuscular dose provides low but persistent serum levels of penicillin for up to 4 weeks.

Yes, Benzathine Penicillin G does not contain any animal-derived components. However, it is always best to check the product packaging or consult your doctor for more information.

Terms & Conditions

List of medicines for Benzathine Penicillin G

Huelin 24 Lac Iu Injection 1
Huelin 24 Lac Iu Injection 1
Jolly Healthcare
Pack of 1 UNITS
₹60
MRP ₹75
20% OFF
Benzathine 1200000 Iu Injection 1
Benzathine 1200000 Iu Injection 1
Karnataka Antibiotics & Pharmaceuticals Ltd(Kapl)
Pack of 1 Units
₹9.28
MRP ₹11.6
20% OFF
Pandural La 1200000 Iu Injection 1 Ml
Pandural La 1200000 Iu Injection 1 Ml
Pfizer Ltd
Pack of 1 ML
₹9.62
MRP ₹12.02
20% OFF
Pencom 1200000 Iu Injection 5 Ml
Pencom 1200000 Iu Injection 5 Ml
Alembic Ltd
Pack of 5 ML
₹8.71
MRP ₹10.89
20% OFF
Benzathine 600000 Iu Injection 1
Benzathine 600000 Iu Injection 1
Karnataka Antibiotics & Pharmaceuticals Ltd(Kapl)
Pack of 1 Units
₹5.92
MRP ₹7.4
20% OFF

Subscribe

Claim your complimentary health and fitness tips subscription and stay updated on our newest promotions.

Registered Office Address

Intellihealth Solutions Private Limited
Unit-301 & 304, Lightbridge Tunga Village, Saki Vihar Rd, Chandivali, Powai, Mumbai, Maharashtra, India, 400072.
CIN: U62099MH2019PTC320566
Telephone:09240250346

Grievance Officer

Name: Kishor Kumar

Download Truemeds

Manage your health with ease Download Truemeds today!Get easy access to medicine refills, health information, and more. With our app, you'll never have to wait in line again. Download now and start taking control of your health.
Playstore
Apple App  Store

Contact Us

Our customer representative team is available 7 days a week from 9 am - 9 pm.


v4.28.9

copyright

2026 - Truemeds | All rights reserved. Our content is for informational purposes only. See additional information.

Trust Certified

Our Payment Partners

paymentPartnerpaymentPartnerpaymentPartnerpaymentPartner
paymentPartnerpaymentPartnerpaymentPartnerpaymentPartner