Benzathine Penicillin G is a long-acting penicillin antibiotic used to treat and prevent certain bacterial infections.
Benzathine Penicillin G is commonly used for:
• Syphilis: Treats infection caused by the bacterium Treponema pallidum at various stages.
• Yaws, bejel, and pinta: Manages these bacterial skin and bone infections common in certain tropical regions.
• Rheumatic fever prevention: Given regularly to prevent recurrent rheumatic fever and reduce the risk of rheumatic heart disease.
• Streptococcal throat infections: Treats mild to moderate upper respiratory tract infections caused by susceptible streptococcal bacteria.
• Prevention of bacterial endocarditis: Used before certain dental procedures in patients at high risk of this heart infection.
Injection site pain, swelling, or redness
Low-grade fever
Nausea and vomiting
Headache
Fatigue
Benzathine Penicillin G is a penicillin-class antibiotic.
It works by binding to and blocking penicillin-binding proteins, which are enzymes bacteria need to build and maintain their cell walls. Without a properly formed cell wall, the bacterial cell becomes unstable and breaks apart.
Because it is formulated to release slowly into the bloodstream after an intramuscular injection, Benzathine Penicillin G provides a long duration of antibacterial action, which is why it is often used for infections that need sustained treatment or regular prophylactic dosing.

Doctor of Medicine

BAMS, FMC, MD Resident
Benzathine Penicillin G is available for use via the intramuscular route in the form of a suspension for injection.
This medicine is meant for both adults and children of age above 12 years.
Benzathine Penicillin G is contraindicated in patients with a history of severe allergic reactions to any penicillin antibiotic.
It is also contraindicated in patients with a history of anaphylaxis to any allergen.
This medicine can interact with antigout agents (such as probenecid), antimetabolites (such as methotrexate), and aminoglycosides (like gentamicin and neomycin).
If this medicine is being given on a regular schedule to prevent recurrent infection, contact your doctor as soon as possible if you miss a scheduled injection, so it can be rearranged. Do not attempt to self-administer a missed or extra dose.
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of fluids can help manage side effects such as nausea and diarrhoea.
Rest techniques can help manage the feelings of fatigue.
Cool compresses or a gentle massage can help manage the pain, swelling or redness at the injection site.
This medication may affect your ability to drive or operate heavy machinery due to side effects such as dizziness. Avoid such activities if these symptoms occur.
It is advisable to consult your doctor before using this medicine during pregnancy and breastfeeding.
Benzathine Penicillin G should be used with caution in patients with a history of allergies, especially to penicillins or cephalosporins.
Patients with kidney dysfunction may require a reduced dosage of this medicine.
Maintain good personal hygiene to prevent recurrent infections.
Regular check-ups with your doctor can help monitor the progress and effectiveness of the medication.
If you have been diagnosed with a sexually transmitted disease, ensure you follow safe sex practices to avoid spreading it to others.
Frequently asked questions
Benzathine Penicillin G is not associated with influencing drowsiness. However, individual reactions can vary, and if you experience any unusual symptoms, you should consult your doctor.
Benzathine Penicillin G is not directly associated with affecting weight gain. If you notice any significant weight changes, it is advisable to consult your doctor.
Benzathine Penicillin G is not associated with affecting menstrual periods. If you notice any changes in your menstrual pattern while on this medication, please consult your doctor.
Yes, Benzathine Penicillin G usually requires a prescription from a doctor and is not available over the counter.
No, Benzathine Penicillin G is not a steroid. It is an antibiotic medicine used to manage certain bacterial infections.
Benzathine Penicillin G stays in the body for an extended period after being injected into a muscle. A single intramuscular dose provides low but persistent serum levels of penicillin for up to 4 weeks.
Yes, Benzathine Penicillin G does not contain any animal-derived components. However, it is always best to check the product packaging or consult your doctor for more information.
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