Alendronate (Alendronic Acid) + Vitamin D3 (Cholecalciferol) is a combination medicine used to manage osteoporosis in men and women.
This combination is commonly used for:
• Osteoporosis: Slows bone loss and helps increase bone density in postmenopausal women and men at risk of fractures.
• Corticosteroid-induced osteoporosis: Manages bone loss caused by long-term corticosteroid use.
• Paget's disease of bone: Helps manage abnormal bone growth and turnover associated with this condition.
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Alendronate (Alendronic Acid) + Vitamin D3 (Cholecalciferol) is a combination that helps treat and prevent osteoporosis.
Alendronate is a bisphosphonate. It binds to bone surfaces and slows down the activity of osteoclasts, the cells responsible for breaking down bone tissue. This reduces bone loss and helps maintain bone strength and density.
Vitamin D3 (Cholecalciferol) improves the absorption of calcium and phosphate from the intestines, supplying the raw materials needed by osteoblasts, the cells that build new bone tissue.
Together, Alendronate slows bone breakdown while Vitamin D3 supports the formation of new, healthy bone.

Doctor of Medicine

BAMS, FMC, MD Resident
Alendronate / Alendronic Acid + Vitamin D3 (Cholecalciferol) is available in the form of a tablet.
This medication is intended for use in adults of age above 18 years.
This medicine is contraindicated in patients with low blood calcium levels (hypocalcaemia).
It should not be used by individuals with severe kidney impairment or abnormalities of the oesophagus that delay emptying such as stricture or achalasia.
Alendronate / Alendronic Acid + Vitamin D3 (Cholecalciferol) may interact with antacids (such as magnesium hydroxide and aluminium hydroxide) and nonsteroidal anti-inflammatory medicines (like aspirin and ibuprofen).
Taking more than the prescribed dose may cause nausea, heartburn, abdominal pain, diarrhoea, or numbness and tingling around the mouth, hands, or feet. Inform your doctor immediately if you experience these symptoms after taking more than your prescribed dose.
If a dose is missed, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drink plenty of fluids to help manage side effects like nausea and diarrhoea.
Try taking the medication with a light snack or at bedtime to manage stomach upset.
This medication does not usually affect your ability to drive or operate machinery. However, if you experience dizziness or other side effects that may impair your alertness, avoid these activities until the symptoms subside.
It is advised to consult your doctor before using this medicine during these periods.
Patients with upper gastrointestinal problems such as Barrett's esophagus, dysphagia, or gastritis should use this medication with caution.
The medication should be used cautiously in patients with kidney dysfunction.
Include foods rich in calcium and vitamin D in your diet to support bone health.
Engage in weight-bearing exercises like walking or lifting weights to increase bone strength.
Frequently asked questions
Alendronate / Alendronic Acid + Vitamin D3 (Cholecalciferol) is not directly associated with affecting menstrual cycles. However, if you notice any changes in your cycle, please consult your doctor.
While Alendronate / Alendronic Acid + Vitamin D3 (Cholecalciferol) is not generally associated with mood changes, everyone's response can differ. If you experience significant mood changes while taking this medication, it is vital to consult your doctor.
Do not worry if you have swallowed the tablet whole as that is the correct way to take it. The tablet should never be crushed, chewed, or sucked on as it can irritate your throat and stomach.
No, even if you are feeling better, do not stop taking the medication without consulting your doctor. It's important to complete the full course of treatment for effective management of your condition.
The medication begins to work on the bones right after the first dose but visible effects like increased bone density might take several months to be noticeable on tests.
Alendronate / Alendronic Acid + Vitamin D3 (Cholecalciferol) is not associated with affecting weight gain. However, everyone reacts differently to medications, so if you notice any significant changes in your weight while taking it, make sure to consult your doctor.
No, Alendronate / Alendronic Acid + Vitamin D3 (Cholecalciferol) is not a steroid. It is a combination medication that includes bisphosphonate (Alendronate/Alendronic acid) and Vitamin D3 (Cholecalciferol) used in the management of osteoporosis.
Alendronate / Alendronic Acid + Vitamin D3 (cholecalciferol) in other salts






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