Ademetionine
Uses of Ademetionine
- Ademetionine is primarily used to treat liver diseases like intrahepatic cholestasis and biliary cholangitis, and also helps manage depression, osteoarthritis, and liver conditions by supporting cartilage production, reducing inflammation, and relieving pain.
- In liver disease, it works by controlling liver glutathione levels, preventing liver damage, and reducing the buildup of cirrhosis-related lipids outside the liver.
- Additionally, it helps restore serotonin balance in the brain and is beneficial in conditions where bile production is reduced.
Side effects of Ademetionine
- Abdominal discomfort
- Abdominal pain
- Diarrhea
- Nausea
- Dizziness
How Ademetionine works
- Ademetionine is an organic compound known as 5'-deoxy-5'-thionucleosides.
- It serves as a methyl donor in numerous methylation reactions, helping to maintain sufficient levels of the antioxidant glutathione in the liver. This action minimises liver damage and prevents an increase of lipids associated with certain liver conditions. Another aspect of its mechanism involves affecting neurotransmitters, like serotonin, which play a vital role in mood regulation. This interaction potentially contributes to its antidepressant effects.
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Reviewed By
BDS, MDS
Expert Advice
Dosage Forms Available
- Ademetionine is available for use via oral (enteric-coated tablets) and intravascular or intramuscular route (injection).
Age and Dose Restrictions
- This medicine is primarily meant for adult use. However, it can be given to children under extreme caution and only if recommended by a doctor.
Contraindications
- This medicine is contraindicated in patients with known allergies to Ademetionine. Patients with bipolar depression and certain liver diseases like biliary obstruction, liver impairment, variceal bleeding, ascites, and liver encephalopathy should avoid using this medicine.
Other Medications to Avoid
- Ademetionine may interact with monoamine oxidase inhibitors (e.g., moclobemide, phenelzine), antidepressants (e.g., bupropion, fluoxetine), antiparkinsonian medicines (e.g., levodopa, carbidopa), and painkillers (e.g., tramadol, acetaminophen).
Overdose and Missed Dose
- An overdose of Ademetionine may lead to serious health issues such as constipation, insomnia (difficulty in sleeping) and dizziness. If you suspect an overdose, seek medical attention immediately.
- If you forget to take a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
- Abdominal discomfort or pain can be managed by taking the medication with meals.
- Diarrhoea may be managed by drinking plenty of fluids to avoid dehydration.
Use in Driving and Operating Machinery
- Ademetionine may cause feelings of dizziness and sleepiness. If you experience these side effects, avoid driving or operating heavy machinery until you feel well enough.
Use in Pregnancy and Lactation
- It is recommended to consult a doctor before using Ademetionine during pregnancy or while breastfeeding.
Caution in Other Conditions
- Patients suffering from diabetes and Parkinson's disease should exercise caution while taking Ademetionine.
Special Dietary and Lifestyle Recommendations
- Avoid high-fat, trans-fat, processed foods, white bread, white pasta, and sugars.
Frequently asked questions
Is Ademetionine a steroid?
No, Ademetionine is not a steroid. It is a naturally occurring substance found in cells, tissues, and bodily fluids.
Does Ademetionine Have Any Effect on Sleep?
Ademetionine may cause insomnia as one of its side effects. This means that some people who take this medicine may find it difficult to sleep.
Will Ademetionine Affect Fertility?
Currently, there is no evidence to suggest that Ademetionine has an effect on fertility. However, if you are planning to conceive, it is best to consult your doctor before taking any medication.
Is It Safe to Take Ademetionine daily?
The duration and frequency of usage will be prescribed by your doctor. It should be followed as per your doctor's advice.
How Much Time Does Ademetionine Take to Work?
The time taken for Ademetionine to show its effects can vary depending on the individual and the condition being managed. Consult your doctor for specific details.
What Is the Best Time to Take Ademetionine?
The best time to take Ademetionine will be determined by your doctor based on your medical condition and response to treatment.
Can alcohol consumption affect the effectiveness of Ademetionine?
Yes, consuming alcohol while taking Ademetionine is not advisable as it may increase drowsiness and risk of liver damage.
What is Ademetionine used for?
Ademetionine is used to treat liver disorders like intrahepatic cholestasis and primary biliary cholangitis, and also supports joint health and mood disorders such as depression. It helps protect the liver by maintaining glutathione levels, reduces inflammation, aids bile flow, and may restore serotonin balance in the brain.
List of Medicines for Ademetionine
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