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Ticagrelor

Antiplatelet

Uses of Ticagrelor

  • Ticagrelor is prescribed for adult patients who have experienced a heart attack or unstable angina in combination with acetylsalicylic acid. It is categorised as an antiplatelet medication.
  • It is also used to reduce the risk of experiencing recurrent heart attacks and strokes resulting from other heart- or blood vessel-related conditions.
     

Side effects of Ticagrelor

  • Headache 
  • Feeling dizzy or like the room is spinning 
  • Abdominal pain, constipation, diarrhoea or indigestion (heartburn) 
  • Nausea or vomiting  
  • Itching  
  • A tingling feeling  

How Ticagrelor works

  • Ticagrelor inhibits the aggregation of blood platelets, reducing the risk of clot formation in blood vessels. By preventing platelets from clumping together, this medicine reduces the likelihood of blood clots, obstructing blood flow and leading to heart attacks or strokes. It helps maintain smooth blood flow in the arteries, reducing the risk of further cardiovascular events.

Certified content

Written By

docImg
Amit SharmaMedical Content Writer| 4 years

B. Pharm

Reviewed By

Amatul Ameen
Amatul Ameen Medical Content Writer| 13 years

B. Pharm, MSc.

Expert Advice

Dosage Forms Available

  • Ticagrelor is available for use via the oral route (tablet).

Age and Dose Restrictions

  • This medicine is meant for adults.

Contraindications

  • The medication is not recommended in patients with a known allergy to Ticagrelor.

Other Medications to Avoid

  • Ticagrelor may interact with several medications, including blood thinners and anticoagulants such as aspirin and warfarin, which can increase the risk of bleeding. It can also interact with pain relievers like ibuprofen, potentially leading to gastrointestinal issues. Antidepressants such as citalopram and nefazodone may enhance the risk of bleeding when taken with Ticagrelor. Additionally, antibiotics like clarithromycin and rifampicin, as well as HIV/AIDS medications such as ritonavir and atazanavir, may alter Ticagrelor's effectiveness. Anti-epileptic medications like phenytoin and carbamazepine, cholesterol-lowering medicines such as simvastatin, and heart medications like digoxin may also interact with Ticagrelor, requiring medical supervision to prevent adverse effects.

Overdose and Missed Dose

  • An overdose of this medication may cause symptoms like excessive bleeding, shortness of breath, and pauses in heartbeat. If you observe these symptoms, inform your doctor and follow the advice accordingly.
  • If you forget to take this medicine, take it as soon as you remember. But avoid repeating the dose.

Management of Side Effects

  • Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

Use in Driving and Operating Machinery

  • This medication may impair your ability to drive and operate heavy machinery.

Use in Pregnancy and Lactation

  • Consult your doctor before using this medicine in pregnancy or lactation.

Caution in Other Conditions

  • Ticagrelor is not recommended for individuals with certain medical conditions due to the risk of severe complications. People with active stomach ulcers may experience increased bleeding, while those with haemophilia, a bleeding disorder, are at a higher risk of uncontrolled bleeding. Individuals with a history of haemorrhage, such as bleeding in the brain, should avoid Ticagrelor as it may worsen their condition.
  • Avoid alcohol when taking Ticagrelor.

Special Dietary and Lifestyle Recommendations

  • Maintaining a healthy weight and achieving an optimal BMI play a crucial role in improving heart health. 
  • Engaging in at least 30 minutes of physical activity daily can significantly reduce the risk of heart disease. 
  • Smoking cessation is another essential step towards better cardiac health, as it helps improve circulation and lowers the risk of heart-related complications. 
  • A well-balanced diet is key—limiting fatty foods, monitoring cholesterol levels, and incorporating nutrient-rich foods like green leafy vegetables, fish, lean meats, nuts, and dry fruits can contribute to overall heart wellness. 
  • Additionally, managing stress effectively is vital for maintaining a healthy heart. Practices such as yoga and meditation can help promote relaxation and emotional well-being, further supporting cardiovascular health.

Frequently asked questions

Ticagrelor starts working within 30 minutes to 2 hours after taking a dose. However, its full antiplatelet effect may take a few days of regular use to be fully established.

Avoid taking Ticagrelor if you have a history of bleeding disorders, active bleeding, or a recent stroke. Inform your doctor if you have kidney or liver disease, stomach ulcers, or if you are undergoing surgery, as Ticagrelor increases the risk of bleeding. Avoid consuming excessive alcohol and NSAIDs like ibuprofen, which can further increase the bleeding risk.

No, you should not stop Ticagrelor without consulting your doctor, even if you feel well. Stopping it suddenly may increase the risk of a heart attack, stroke, or blood clot formation, especially if you have had stents placed or a history of heart disease.

Ticagrelor should be used with caution in patients with kidney disease. It is not recommended for those with severe liver disease as it may worsen bleeding tendencies. Consult your doctor before using it if you have any kidney or liver problems.

There is limited evidence suggesting that Ticagrelor affects fertility in men or women. However, if you are planning to conceive, consult your doctor to discuss potential risks and alternative options.

Terms & Conditions


Ticagrelor in other salts

List of Medicines for Ticagrelor

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