Prothionamide

Dosage Forms Available

• Prothionamide is available in tablet form. These tablets are intended for oral administration.

Age and Dose Restrictions

• This medicine is meant for adults and children over 12 years of age.

Contraindications

• This medicine is contraindicated in patients with severe liver disease or acute liver failure.

• It is also contraindicated in patients with pre-existing liver impairment.

Other Medications to Avoid

• This combination may interact with other anti-tuberculosis medications (such as isoniazid), antibiotics (like cycloserine), thyroid medications (such as thyroxine), and gastrointestinal agents (sucralfate).

Overdose and Missed Dose

• An overdose of Prothionamide may lead to severe adverse effects such as liver injury or psychiatric symptoms. Immediate medical attention should be sought if an overdose is suspected.

• If you miss a dose of Prothionamide, take it as soon as you remember. However, if it is nearly time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• To manage gastrointestinal disturbances like nausea or vomiting, try taking Prothionamide with food.

• A metallic taste in the mouth may be lessened by rinsing your mouth after taking the medication.

Use in Driving and Operating Machinery

• Prothionamide may cause dizziness or drowsiness. Avoid driving or operating heavy machinery if you experience these symptoms after taking this medicine.

Use in Pregnancy and Lactation

• Prothionamide is not recommended during pregnancy unless needed due to potential risks to the fetus.

• It is advisable to avoid breastfeeding while taking this medicine as it enters breast milk.

Caution in Other Conditions

• Patients with diabetes should monitor their blood glucose levels closely as Prothionamide may lower blood sugar levels.

• Those with a history of psychiatric conditions should also exercise caution due to the potential for psychiatric effects from Prothionamide.

Special Dietary and Lifestyle Recommendations

• Patients taking Prothionamide should regularly monitor their liver function through blood tests, as liver health can be adversely affected by this medication.

• It is advisable to limit alcohol consumption because alcohol can increase the risk of liver toxicity when taking Prothionamide.

• Maintaining adequate hydration can help manage some side effects such as nausea or dizziness.

• Since tuberculosis is a contagious disease, adhering strictly to your prescribed medication regimen is crucial not only for your health but also to prevent the spread of infection to others.